Curative effect and safety of haploidentical allogeneic cytokine-induced killer in treatment of advanced hepatocellular carcinoma
10.3969/j.issn.1674-7445.2015.06.012
- VernacularTitle:同种异体半相合细胞因子诱导的杀伤细胞治疗晚期肝癌的疗效及安全性评估
- Author:
Fan YANG
1
;
Xiaofang ZHENG
;
Chang LIU
;
Wenjie CHEN
;
Jintao CHENG
;
Li YANG
;
Jianxi LU
;
Qi ZHANG
Author Information
1. 中山大学附属第三医院岭南医院生物治疗中心 肝脏疾病生物治疗临床转化广东普通高校重点实验室
- Keywords:
Haploidentical allogeneic;
Cytokine-induced killer;
Hepatocellular carcinoma;
Adverse reaction;
Cell therapy
- From:
Organ Transplantation
2015;(6):405-409
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the curative effect and safety of haploidentical allogeneic cytokine-induced killer (CIK)in treatment of advanced hepatocellular carcinoma.Methods The peripheral blood mononuclear cell (PBMC) of the healthy immediate family members of 21 patients with advanced hepatocellular carcinoma (HCC) were collected,induced into haploidentical allogeneic CIK in vitro and transfused to the patients for 4 cycles.The curative effect and safety were assessed.Results The 21 patients were followed up for half a year.The survival rate was 81 % (1 7 /21 ).Among the 21 patients,1 1 cases were with stable disease and 1 0 cases were with progressive disease (including 4 dead cases).Six patients developed fever of different degrees during the treatment and one patient developed rash.The platelet counts of the patients at the fourth cycle after the treatment decreased compared with that before the treatment ,with significance difference (P <0.05).The difference in leukocytes,neutrophils,lymphocytes,hemoglobin,liver function and renal function at the first and fourth cycle after the treatment had no statistical significance (all in P >0.05 ).Conclusions Haploidentical allogeneic CIK in treatment of advanced HCC may effectively improve the quality of life and the adverse reactions are tolerable,which is a relatively safe therapy.
