Retinoid X receptor signaling pathway in leukemia
10.3969/j.issn.1674-7445.2014.06.013
- VernacularTitle:维A酸X受体信号通路与白血病
- Author:
Xiaoxi LU
1
;
Zhigui MA
;
Ju GAO
;
Yiping ZHU
Author Information
1. 四川大学华西第二医院儿科血液肿瘤科
- Keywords:
Retinoid X receptor;
Signal pathway;
Leukemia;
Bone marrow transplantation
- From:
Organ Transplantation
2014;(6):383-388
- CountryChina
- Language:Chinese
-
Abstract:
Retinoid X receptor (RXR) acts as ligand-dependent transcription factors playing an important role in regulating a serial of physiological processes,such as embryo development and organ homeostasis.At the molecular level,RXRs exert their functions by inter-activating with multiple signal pathways to regulate target gene expression which control cell growth,differentiation,survival and death.The interference in the network of RXR and other signal pathways has turned RXR into an attractive drug target.
