Effect of two biological immunologic induction therapies on renal transplant recipients
10.3969/j.issn.1674-7445.2014.05.008
- VernacularTitle:两种生物免疫诱导方案对肾移植受者的影响
- Author:
Jian LI
1
;
Yahong XU
;
Yu GUO
;
Xiaoping MA
;
Yi LU
;
Yangbo LI
;
Zhigang JIA
;
Qihua ZHAO
;
Shunwen LUO
;
Ping CHEN
Author Information
1. 解放军第452医院泌尿外科暨成都军区泌尿外科中心
- Keywords:
Renaltransplantation;
Immunologicinductiontherapy;
Basiliximab;
Antithymocyte globulin;
Infection;
Delayed graft function
- From:
Organ Transplantation
2014;(5):299-303
- CountryChina
- Language:Chinese
-
Abstract:
Objective Toevaluateefficacyandsafetyoftwodifferentbiologicalsinimmunologic inductiontherapyonrenaltransplantrecipients.Methods Clinicaldataof78renaltransplantrecipientswho received biological immunologic induction therapy in Department of Urology of the 452nd Hospital of Chinese People's Liberation Army from June 2008 to April 2013,were retrospectively analyzed. According to different biological immunologic induction therapy,the recipients were divided into two groups,monoclonal antibody group (group A,n=35,received treatment of basiliximab)and polyclonal antibody group [group B,n=43, received treatment of antithymocyte globulin (ATG)]. And the other recipients who didn't receive immunologic induction therapy in the hospital during the corresponding period were chosen as control group (group C,n=32). The survival rates of recipient and kidney in 3 groups at 12th weeks after transplantation were analyzed.The levels of serum creatinine (Scr)of recipients in 3 groups were monitored at 7,14,30,60 d after transplantation. The occurrence rates of complications including acute rejection,delayed graft function and infectionwerecomparedamong3groups.Results At12thweeksaftertransplantation,thesurvivalratesof recipient and kidney in 3 groups were 100% and 100% in group A,97.7% and 97.7% in group B,100%and 96.9% in group C. There was no significant difference among 3 groups (all in P>0.05 ). Compared with group C,the Scr levels in group A and B decreased significantly at 7,14 d after transplantation (all in P<0.05 ). Compared with group C,the incidence rates of acute rejection decreased in group A and B(all in P<0.05 ). There was no significant difference in the incidence rates of delayed graft function among 3 groups (all in P>0.05 ). The incidence rate of infection in group B was significantly higher than those in group A and C (allinP<0.05).Conclusions Immunologicinductiontherapyissafeandeffectiveintheapplicationon renal transplant recipients.
