Research progress of mast cells in the mechanism of intestinal injury caused by deep hypothermic circulatory arrest
10.7507/1007-4848.201803051
- VernacularTitle:肥大细胞在深低温停循环肠损伤作用机制中的研究进展
- Author:
BAI Liting
1
;
ZHANG Yanbo
1
;
LI Tong
1
;
GUO Shengwen
1
Author Information
1. Department of SICU, Fuwai Hospital, Peking Union Medical College, State Key Laboratory of Cardiovascular Disease, National Center of Cardiovascular Disease, Beijing, 100037, P.R.China
- Publication Type:Journal Article
- Keywords:
Deep hypothermic circulatory arrest;
intestinal injury;
mast cell
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2019;26(3):269-273
- CountryChina
- Language:Chinese
-
Abstract:
Deep hypothermic circulatory arrest (DHCA) is an important assistant technique for complex cardiac surgery, which creates convenient operating conditions for surgery, and is also one of the measures to protect the brain during operation. However, the complications caused by this technique cannot be ignored, and it should be noticed that the occurrence of intestinal injury is relatively insidious, but brings great pain to patients and significantly reduces the quality of life after operation. Studies have shown that intestinal ischemia-reperfusion injury is induced by DHCA. It causes mast cells to activate and release many inflammatory mediators that destroy the intestinal mucosal epithelium barrier, and eventually lead to intestinal injury. This article reviewed the research progress of mast cells in the mechanism of DHCA-induced intestinal injury.
