METHODS: This was a cross-sectional study. The FAZ area was measured in 69 participants, for a total of 138 eyes, using RTVue-100 OCT. The relations between the FAZ area and the potential factors were evaluated by univariate and multivariate linear regression analysis. Differences between the right and left eyes were calculated, and values were compared by means of a paired t test. Pearson correlation analysis was performed to assess the relationships of the FAZ area between the right and left eyes.

RESULTS: The mean FAZ area was 0.30±0.11mm² in all subjects. For the male subjects, the mean FAZ area was 0.29±0.13mm², and for the female subjects 0.31±0.09mm², with no significant difference(t=-1.346,P=0.180). The FAZ area did not correlate with all the potential factors. The mean FAZ area in the right eye was 0.30±0.11mm², and in the left eye was 0.30±0.10mm²,with no significant difference(P=0.943). There was a strong correlation between the right and left eyes for the FAZ area.

CONCLUSION: OCT angiography is a noninvasive method of visualizing and measuring the FAZ area in normal subjects. The FAZ area does not correlate with old age, sex and other factors. It shows significant interocular symmetry in normal subjects.