Latest progress of BIGH3 gene in corneal diseases and diabetic retinopathy
10.3980/j.issn.1672-5123.2017.3.14
- VernacularTitle:BIGH3基因在角膜疾病及糖尿病视网膜病变中的研究新进展
- Author:
Fan-Qian Song
1
Author Information
1. Eye Hospital, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
- Publication Type:Journal Article
- Keywords:
BIGH3;
corneal neovascularization;
corneal dystrophy;
keratoconus;
diabetic retinopathy
- From:
International Eye Science
2017;17(3):449-450
- CountryChina
- Language:Chinese
-
Abstract:
BIGH3 gene plays an important role in ocular diseases. On the one hand, it is closely related to the occurrence of corneal diseases. BIGH3 gene can inhibit corneal neovascularization, lead to corneal dystrophy, participate in keratoconus formation. On the other hand, it can lead to the formation of neovascularization in diabetic retinopathy. The latest experiments show that TGF beta secreted by macrophages can promote the expression of BIGH3 mRNA and BIGH3 protein, and promote apoptosis of retinal endothelial cells and pericytes, which leads to the formation of neovascularization in diabetic retinopathy. This article will describe the new progress of BIGH3 gene in ocular diseases from several aspects as mentioned above.
