Research progress on the regulation of BMP4 on ocular cells

VernacularTitle:BMP4对眼部细胞调控作用的研究进展
Author: Jia-Ming Liang ^{1
,

2}
Author Information

1. 1Laser Myopia Correcting Center, the Second Hospital of Jilin University, Changchun 130041, Jilin Province, China
2. 2Clinical Medical College of Jilin University, Changchun 130000, Jilin Province, China
Publication Type:Journal Article
Keywords: bone morphogenetic protein 4; regulation; cell
From: International Eye Science 2017;17(5):901-903
CountryChina
Language:Chinese
Abstract: Bone morphogenetic proteins(BMPs)belongs to the transforming growth factor beta(TGF-β)superfamily, which was isolated from the decalcified bone matrix by Urist in 1965.As one of the members of BMPs family, BMP4 not only promotes the differentiation and development of chondrocytes, but also plays an important role in the regulation of eye cells. BMP4 can mediate apoptosis of retinal vascular endothelial cells and inhibit angiogenesis, and is expressed in adult corneal epithelium, corneal cells and corneal endothelial cells. Also, participated in the layered corneal epithelium cells proliferation. In this paper, the recent advances in the study of BMP4 in ocular tissues are summarized, and the function of BMP4 in different developmental stages of eye is briefly reviewed.