Physiological mechanisms of prostaglandin analogues on lowing intraocular pressure
10.3980/j.issn.1672-5123.2017.5.20
- VernacularTitle:前列腺素衍生物类药物降眼压的作用机制
- Author:
Wei Song
1
Author Information
1. Department of Ophthalmology, Jiaxing Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University, Jiaxing 314000, Zhejiang Province, China
- Publication Type:Journal Article
- Keywords:
glaucoma;
prostaglandin analogue;
trabecular meshwork-Schlemm's canal pathway;
uveoscleral pathway
- From:
International Eye Science
2017;17(5):884-887
- CountryChina
- Language:Chinese
-
Abstract:
Pathological elevation of intraocular pressure(IOP)is the most prevalent risk factor in the development and progress of glaucoma. Up to date, all treatments for glaucoma are aimed to lower IOP through surgeries and drugs. Prostaglandin analogues are the first-line IOP-lowing drugs for glaucoma due to their ability to reduce IOP. Enough evidences have suggested that they increase aqueous humor outflow through uveoscleral pathway. More recently, people found that bimatoprost was able to increase aqueous humor outflow through trabecular meshwork-Schlemm's canal pathway. Nowadays, a large number of studies are performed to study the mechanism of prostaglandin analogues on lowing intraocular pressure.
