Odor-Dependent Hemodynamic Responses Measured with NIRS in the Main Olfactory Bulb of Anesthetized Rats.
- Author:
Hyun Joo LEE
1
;
Yunjun NAM
;
Chin Su KOH
;
Changkyun IM
;
In Seok SEO
;
Seungjin CHOI
;
Hyung Cheul SHIN
Author Information
- Publication Type:Original Article
- Keywords: near-infrared spectroscopy (NIRS); hemodynamic response; main olfactory bulb (MOB); non-invasive; odorant; brain-machine interface (BMI)
- MeSH: Animals; Benzene Derivatives; Hemodynamics; Hemoglobins; Ketones; Odors; Olfactory Bulb; Oxygen; Rats; Spectroscopy, Near-Infrared
- From:Experimental Neurobiology 2011;20(4):189-196
- CountryRepublic of Korea
- Language:English
- Abstract: In this study, we characterize the hemodynamic changes in the main olfactory bulb of anesthetized Sprague-Dawley (SD) rats with near-infrared spectroscopy (NIRS, ISS Imagent) during presentation of two different odorants. Odorants were presented for 10 seconds with clean air via an automatic odor stimulator. Odorants are: (i) plain air as a reference (Blank), (ii) 2-Heptanone (HEP), (iii) Isopropylbenzene (IB). Our results indicated that a plain air did not cause any change in the concentrations of oxygenated (Delta[HbO2]) and deoxygenated hemoglobin (Delta[Hbr]), but HEP and IB induced strong changes. Furthermore, these odor-specific changes had regional differences within the MOB. Our results suggest that NIRS technology might be a useful tool to identify of various odorants in a non-invasive manner using animals which has a superb olfactory system.
