Ultrasound-guided drug delivery in cancer.
- Author:
Sayan MULLICK CHOWDHURY
1
;
Taehwa LEE
;
Jürgen K WILLMANN
Author Information
- Publication Type:Review
- Keywords: Ultrasonography; Drug delivery systems; Cancer therapy; Genetic therapy; Microbubbles
- MeSH: Drug Delivery Systems; Genetic Therapy; Microbubbles; Ultrasonography
- From: Ultrasonography 2017;36(3):171-184
- CountryRepublic of Korea
- Language:English
- Abstract: Recent advancements in ultrasound and microbubble (USMB) mediated drug delivery technology has shown that this approach can improve spatially confined delivery of drugs and genes to target tissues while reducing systemic dose and toxicity. The mechanism behind enhanced delivery of therapeutics is sonoporation, the formation of openings in the vasculature, induced by ultrasound-triggered oscillations and destruction of microbubbles. In this review, progress and challenges of USMB mediated drug delivery are summarized, with special focus on cancer therapy.
