Portable high-intensity focused ultrasound system with 3D electronic steering, real-time cavitation monitoring, and 3D image reconstruction algorithms: a preclinical study in pigs.
- Author:
Jin Woo CHOI
1
;
Jae Young LEE
;
Eui Jin HWANG
;
Inpyeong HWANG
;
Sungmin WOO
;
Chang Joo LEE
;
Eun Joo PARK
;
Byung Ihn CHOI
Author Information
1. Department of Radiology and Institute of Radiation Medicine, Seoul National University Hospital, Seoul, Korea. leejy4u@snu.ac.kr
- Publication Type:Original Article
- Keywords:
High-intensity focused ultrasound ablation;
Ablation techniques;
Animal research;
Equipment and supplies
- MeSH:
Ablation Techniques;
Animal Experimentation;
Animals;
Equipment and Supplies;
High-Intensity Focused Ultrasound Ablation;
Image Processing, Computer-Assisted*;
Kidney;
Sonication;
Swine*;
Thigh;
Transducers;
Ultrasonography*;
Water
- From:
Ultrasonography
2014;33(3):191-199
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The aim of this study was to evaluate the safety and accuracy of a new portable ultrasonography-guided high-intensity focused ultrasound (USg-HIFU) system with a 3-dimensional (3D) electronic steering transducer, a simultaneous ablation and imaging module, real-time cavitation monitoring, and 3D image reconstruction algorithms. METHODS: To address the accuracy of the transducer, hydrophones in a water chamber were used to assess the generation of sonic fields. An animal study was also performed in five pigs by ablating in vivo thighs by single-point sonication (n=10) or volume sonication (n=10) and ex vivo kidneys by single-point sonication (n=10). Histological and statistical analyses were performed. RESULTS: In the hydrophone study, peak voltages were detected within 1.0 mm from the targets on the y- and z-axes and within 2.0-mm intervals along the x-axis (z-axis, direction of ultrasound propagation; y- and x-axes, perpendicular to the direction of ultrasound propagation). Twenty-nine of 30 HIFU sessions successfully created ablations at the target. The in vivo porcine thigh study showed only a small discrepancy (width, 0.5-1.1 mm; length, 3.0 mm) between the planning ultrasonograms and the pathological specimens. Inordinate thermal damage was not observed in the adjacent tissues or sonic pathways in the in vivo thigh and ex vivo kidney studies. CONCLUSION: Our study suggests that this new USg-HIFU system may be a safe and accurate technique for ablating soft tissues and encapsulated organs.
