Theragnostic ultrasound using microbubbles in the treatment of prostate cancer.
- Author:
Hak Jong LEE
1
;
Young Il YOON
;
Yun Jung BAE
Author Information
- Publication Type:Review
- Keywords: Prostate; Microbubbles; Ultrasonography
- MeSH: Americas; Asian Continental Ancestry Group; Capillary Permeability; Colorectal Neoplasms; Contrast Media; Drug Carriers; Europe; Humans; Incidence; Japan; Korea; Ligands; Lung; Microbubbles*; Perfusion; Prostate*; Prostatic Neoplasms*; Ultrasonography*
- From: Ultrasonography 2016;35(4):309-317
- CountryRepublic of Korea
- Language:English
- Abstract: The use of gas-filled microbubbles in perfusion monitoring as intravascular ultrasound contrast agents has recently become more common. Additionally, microbubbles are employed as carriers of pharmaceutical substances or genes. Microbubbles have great potential to improve the delivery of therapeutic materials into cells and to modify vascular permeability, causing increased extravasation of drugs and drug carriers. Prostate cancer is the most common neoplasm in Europe and America, with an incidence twice to three times that of lung and colorectal cancer. Its incidence is still rising in Asian countries, including Japan and Korea. In this review, we present current strategies regarding the synthesis of microbubbles with targeted ligands on their surfaces, with a focus on prostate cancer.
