A Case of P-ANCA Positive Necrotizing Glomerulonephritis with Eosinophilia.
- Author:
Jang Yel SHIN
1
;
Ea Wha KANG
;
Dong Ryeol RYU
;
Jung Sik SONG
;
Won Ki LEE
;
Yong Beom PARK
;
Lucia KIM
;
Heun Ju JUNG
;
Soo Kon LEE
Author Information
1. Departmenrt of Internal Medicine, College of Medicine, Yonsei University, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
ANCA;
Pauci-immune crescentic necrotizing glomerulonephritis;
Eosinophilia
- MeSH:
Antibodies, Antineutrophil Cytoplasmic*;
Asthma;
Churg-Strauss Syndrome;
Cyclophosphamide;
Cytoplasm;
Eosinophilia*;
Eosinophils;
Fluorescent Antibody Technique, Indirect;
Glomerulonephritis*;
Granuloma;
Humans;
Neutrophils;
Peroxidase;
Prednisolone;
Systemic Vasculitis;
Vasculitis
- From:The Journal of the Korean Rheumatism Association
2000;7(1):83-89
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Antineutrophil cytoplasmic antibodies (ANCAs) are now regarded as a serologic marker for pauci-immune crescentic necrotizing glomerulonephritis either in renal-limited form or in association with systemic vasculitis, such as Wegener? granulomatosis, microscopic polyarteritis, and Churg-Strauss syndrome. Two major ANCA antigens have been indentified: proteinase3, which produces a cytoplasmic staining pattern termed C-ANCA, and myeloperoxidase, which produces a perinuclear pattern termed P-ANCA on ethanol-fixed neutrophils by indirect immunofluorescence. In ANCA- associated diseases, eosinphilia in excess of 1.5X109/L has been proposed to be characteristic of Churg-Strauss syndrome and is rare in other forms of ANCA-associated systemic vasculitis and crescentic necrotizing glomerulonephritis. Recently, there were two cases of P-ANCA positive crescentic necrotizing glomerulonephritis with peripheral blood eosinophilia and extrarenal microscopic vasculitis without asthma or granulomas. We experienced a patient with P-ANCA positive pauci-immune necrotizing glomerulonephritis with few eosinophilic infiltration and eosinophilia. He improved with oral prednisolone along with combination of intravenous cyclophosphamide. So we report this case with the review of literature.
