Endovascular Embolization of Intracranial Aneurysms Using Bare Platinum Axium(TM) Detachable Coils: Immediate and Short-Term Follow-up Results from a Multicenter Registry.
10.5469/neuroint.2012.7.2.85
- Author:
Byung Moon KIM
1
;
Dong Joon KIM
;
Pyoung JEON
;
Pyung Ho YOON
;
Byung Hee LEE
;
Myeong Sub LEE
;
Tae Hong LEE
;
Jun Soo BYUN
;
Dong Ik KIM
Author Information
1. Department of Radiology, Severance Hospital, College of Medicine, Yonsei University, Seoul, Korea. dikim@yuhs.ac
- Publication Type:Multicenter Study ; Original Article
- Keywords:
Aneurysm;
Coiling;
Endovascular treatment
- MeSH:
Aneurysm;
Angiography;
Catheters;
Follow-Up Studies;
Humans;
Intracranial Aneurysm;
Logistic Models;
Neck;
Platinum;
Prospective Studies;
Retrospective Studies
- From:Neurointervention
2012;7(2):85-92
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Axium(TM) coils were developed to improve the durability of coil-embolized cerebral aneurysms by increasing packing density. The purpose of this prospective multicenter registry was to evaluate the safety and durability of Axium(TM) coils. MATERIALS AND METHODS: One hundred twenty-six patients with 135 aneurysms of < or = 15 mm in size underwent coil embolization using bare platinum coils, with Axium(TM) coils constituting over 50% of the total coil length. Immediate and short-term follow-up results were prospectively registered and retrospectively evaluated. RESULTS: Of the 135 aneurysms (83 unruptured and 52 ruptured), immediate post-embolization angiography revealed complete occlusion in 80 aneurysms (59.3%), neck remnants in 47 (34.8%), and incomplete occlusion in 8 (5.9%). The mean packing density was 42.8% (range, 9.5 - 90%) with Axium(TM) coil length constituting a mean of 87.9% of total coil length. The rate of procedure-related complications was 16.3%. Procedure-related permanent morbidity and mortality rates were 3.2% and 0.8%, respectively. Follow-up catheter or MR angiography, which was available in 101 aneurysms at 6 - 15 months (mean, 7.7 months), revealed stable or improved occlusion in 95 aneurysms and worsening in 6 aneurysms (5.9%). Lower packing density (< 30%) remained the only predictor for anatomical worsening on multivariable logistic regression analysis (P < 0.05). CONCLUSION: In this registry, Axium(TM) coils showed a relatively low rate of anatomical worsening on short-term follow-up imaging with an acceptable periprocedural safety profile compared to reports of other platinum coils. These results may warrant further study of long-term durability with Axium(TM) coils in larger populations.
