Biological Screening of a Novel Nickel (II) Tyrosine Complex.
- Author:
Md Rafiqul ISLAM
1
;
S M Rafiqul ISLAM
;
Abu Shadat Mohammod NOMAN
;
Jahan Ara KHANAM
;
Shaikh Mohammad Mohsin ALI
;
Shahidul ALAM
;
Min Woong LEE
Author Information
1. Genetic Engineering Department, Chittagong University, Chittagong-4331, Bangladesh.
- Publication Type:Original Article
- Keywords:
Antimicrobial activity;
Cytotoxicity;
Nickel (II) tyrosine complex;
Pathogens
- MeSH:
Agar;
Artemia;
Aspergillus flavus;
Aspergillus niger;
Bacteria;
Biological Assay;
Candida albicans;
Escherichia coli;
Fungi;
Mass Screening*;
Microbial Sensitivity Tests;
Mortality;
Nickel*;
Penicillium;
Shigella;
Streptococcus;
Tyrosine*
- From:Mycobiology
2007;35(1):25-29
- CountryRepublic of Korea
- Language:English
-
Abstract:
A newly synthesized Nickel (II) tyrosine complex was screened as potential antimicrobial agent against a number of medically important bacteria (Bacillus subtilis, Streptococcus beta-haemolytica, Escherichia coli, Shigella dysenterae) and fungi (Aspergillus fumigatus, Candida albicans, Aspergillus niger, Aspergillus flavus, Penicillium sp.) strains. were used for antifungal activity. The antimicrobial activity was evaluated using the Agar Disc method. Moreover, the minimum inhibitory concentration of the complexes was determined against the same pathogenic bacteria and the values were found between 4~64 microg ml(-1). Brine shrimp bioassay was carried out for cytotoxicity measurements of the complexes. The LC50 values were calculated after probit transformation of the resulting mortality data and found to be 6 microg ml(-1).
