Production of Antihypertensive Angiotensin I-Converting Enzyme Inhibitor from Malassezia pachydermatis G-14.
10.4489/MYCO.2005.33.3.142
- Author:
Seung Chan JEONG
1
;
Jae Ho KIM
;
Na Mi KIM
;
Jong Soo LEE
Author Information
1. Department of Genetic Engineering and Bio-medicinal Resource Research Center, Paichai University, Daejeon 302-735, Korea. biotech8@mail.pcu.ac.kr
- Publication Type:Original Article
- Keywords:
Angiotensin I-converting enzyme inhibitor;
Antihypertensive;
Malassezia pachydermatis
- MeSH:
Angiotensins*;
Cultural Characteristics;
Glucose;
Malassezia*;
Peptidyl-Dipeptidase A*;
Peptones;
Yeasts
- From:Mycobiology
2005;33(3):142-146
- CountryRepublic of Korea
- Language:English
-
Abstract:
To produce a novel antihypertensive angiotensin I-converting enzyme (ACE) inhibitor from yeast, a yeast isolate, designated G-14 showing the highest ACE inhibitory activity was obtained and identified as Malassezia pachydermatis based on morphological, biochemical and cultural characteristics. The maximal extracellular ACE inhibitor production was obtained from M. pachydermatis G-14 when the strain was cultured in YEPD medium containing 0.5% yeast extract, 3.0% peptone and 2.0% glucose at 30degrees C for 24 h and the final ACE inhibitory activity was 48.9% under the above condition.
