Azole Resistance Caused by Increased Drug Efflux in Candida glabrata Isolated from the Urinary Tract of a Dog with Diabetes Mellitus.
10.5941/MYCO.2017.45.4.426
- Author:
Minchul KIM
1
;
Hyekyung LEE
;
Sun Young HWANG
;
Inhyung LEE
;
Won Hee JUNG
Author Information
1. Department of Systems Biotechnology, Chung-Ang University, Anseong 17546, Korea. whjung@cau.ac.kr
- Publication Type:Brief Communication
- Keywords:
Azole resistance;
Candida glabrata;
Diabetes;
Dog;
Drug efflux;
Urinary tract
- MeSH:
Adenosine Triphosphate;
Animals;
Candida glabrata*;
Candida*;
Child;
Danazol*;
Diabetes Mellitus*;
Dogs*;
Drug Resistance;
Fungi;
Humans;
Ketosis;
Male;
Pancreatitis;
Urinary Tract Infections;
Urinary Tract*
- From:Mycobiology
2017;45(4):426-429
- CountryRepublic of Korea
- Language:English
-
Abstract:
A yeast-like organism was isolated from a urine sample of a 6-year-old neutered male miniature poodle dog with urinary tract infection, diabetes ketoacidosis, and acute pancreatitis. We identified the yeast-like organism to be Candida glabrata and found that this fungus was highly resistant to azole antifungal drugs. To understand the mechanism of azole resistance in this isolate, the sequences and expression levels of the genes involved in drug resistance were analyzed. The results of our analysis showed that increased drug efflux, mediated by overexpression of ATP transporter genes CDR1 and PDH1, is the main cause of azole resistance of the C. glabrata isolated here.
