Successful Desensitization of A Case of Anaphylaxis to Insulin.
- Author:
Jeong Hoon JANG
;
Young Gull KIM
;
Ai Young LEE
- Publication Type:Case Report
- Keywords:
Insulin;
Anaphylaxis
- MeSH:
Anaphylaxis*;
Diabetes Mellitus, Type 1;
Follow-Up Studies;
Humans;
Hypersensitivity;
Immunoglobulin E;
Injections, Subcutaneous;
Insulin*;
Insulins;
Intradermal Tests;
Male;
Middle Aged;
Skin Tests
- From:Korean Journal of Dermatology
1998;36(6):1146-1148
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A small proportion of diabetics treated with exogenous insulin, reportedly ranging from 0.1% to 2%, experience systemic allergic reactions to insulin. We saw a 55-year-old male patient with insulin-dependent diabetes mellitus who had developed an anaphylatic reaction immediately after subcutaneous injections of neutral protamine Hagedorn (NPH) human recombinant insulin. Skin tests with insulins and a passive transfer test demonstrated that his reaction was IgE mediated. Since there were no therapeutic alternatives, desensitization with insulin was done following a slow protocol. It was successful and he was able to resume insulin therapy. During two year follow-up period, he did not developed any adverse reaction to insulin.
