Antibacterial Activity of Water Soluble Components of Elfvingia applanata Alone and in Combinations with Third Generation Cephalosporins.
- Author:
Seong Kug EO
1
;
Young So KIM
;
Chong Kil LEE
;
Young Nam LEE
;
Seong Sun HAN
Author Information
1. College of Pharmacy, Chungbuk National University, Cheongju 361-763, Korea.
- Publication Type:Original Article
- Keywords:
Elfvingia applanata;
Antibacterial activity;
Macrobroth dilution checkerboard assay;
Fractional inhibitory concentration index (FICI)
- MeSH:
Bacteria;
Cefixime;
Cefotaxime;
Ceftazidime;
Ceftriaxone;
Cephalosporins*;
Gram-Negative Bacteria;
Gram-Positive Bacteria;
Proteus vulgaris;
Staphylococcus epidermidis
- From:Mycobiology
2000;28(2):57-61
- CountryRepublic of Korea
- Language:English
-
Abstract:
Antibacterial activity of EA, a preparation of water soluble components made from carpophores of Elfvingia applanata (Pers.) Karst, was examined by macrobroth diltution method against a number of bacterial species. Antibacterial effects of EA were expressed as minimal inhibitory concentration (MIC) for growth. Among twelve species of bacteria tested, six strains of each gram positive bacteria and gram negative bacteria, EA showed the most potent antibacterial activity against Staphylococcus epidermidis and Proteus vulgaris, of which MICs were 1.25 mg/ml of EA. To investigate the antibacterial effects of combinations of EA with third generation cepholosporins, such as cefotaxime, ceftriaxone, ceftazidime, and cefixime, the fractional inhibitory concentration (FIC) and fractional inhibitory concentration index (FICI) were determined by macrodilution checkerboard assay for twelve bacterial strains. Combinations of EA and third generation cephalosporins exhibited either additive or indifferent effects in most instances. However, synergistic effects were observed in six instances. No antagonistic effect was observed in any cases.
