Antitumor Effects and Immunomodulating Activities of Phellinus linteus Extract in a CT-26 Cell-Injected Colon Cancer Mouse Model.
- Author:
Byung Keun YANG
1
;
Seung Lark HWANG
;
Ik Jin YUN
;
Eun Ju DO
;
Won Ha LEE
;
Young Mi JUNG
;
Sung Chang HONG
;
Dong Chan PARK
Author Information
1. Department of Biotechnology, Catholic University of Daegu, Gyungbuk 712-702, Korea. yangbk@cu.ac.kr
- Publication Type:Original Article
- Keywords:
Anticomplementary;
Antitumor;
Colon cancer;
Keumsa Linteusan;
Macrophage lysosomal enzyme;
Mouse model;
Phellinus linteus
- MeSH:
Animals;
Colon;
Colonic Neoplasms;
Immunity, Innate;
Macrophages;
Mice;
Polysaccharides
- From:Mycobiology
2009;37(2):128-132
- CountryRepublic of Korea
- Language:English
-
Abstract:
The antitumor effects of Phellinus linteus extract (Keumsa Linteusan) were investigated in a CT-26 cell-injected colon cancer mouse model. When administered orally (250~1,000 mg/kg body weight), Keumsa Linteusan significantly inhibited the growth of solid colon cancer. The highest dose was highly effective, reducing tumor formation by 26% compared with the control group. The anticomplementary activity of Keumsa Linteusan increased in a dose-dependent manner. Lysosomal enzyme activity of macrophages was increased by 2-fold (100 microg/ml) compared with the control group. Keumsa Linteusan can be regarded as a potent enhancer of the innate immune response, and can be considered as a very promising candidate for antitumor action.
