Maternal antimullerian hormone as a predictor of fetal aneuploidy occurring in an early pregnancy loss.
10.5468/ogs.2015.58.6.494
- Author:
So Hyun SHIM
1
;
Hyeong In HA
;
Yong Wook JUNG
;
Sung Shin SHIM
;
Yeon Kyung CHO
;
Ji Youn KIM
;
Kyoung Jin LEE
;
Dong Hyun CHA
;
Soo Hyun KIM
;
Hee Jin PARK
Author Information
1. Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, Korea. coolsome72@chamc.co.kr
- Publication Type:Multicenter Study ; Original Article
- Keywords:
Abortion, spontaneous;
Aneuploidy;
Anti-mullerian hormone;
Chromosome aberrations;
Follicle stimulating hormone
- MeSH:
Abortion, Spontaneous;
Aneuploidy*;
Anti-Mullerian Hormone*;
Chromosome Aberrations;
Cohort Studies;
Demography;
Female;
Fertility;
Follicle Stimulating Hormone;
Gestational Age;
Gyeongsangbuk-do;
Humans;
Karyotype;
Karyotyping;
Maternal Age;
Medical Records;
Multivariate Analysis;
Pregnancy*;
Retrospective Studies
- From:Obstetrics & Gynecology Science
2015;58(6):494-500
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: The purpose of the study was to examine the relationship between the parameter representing ovarian reserve and the fetal aneuploidy in early spontaneous miscarriage. METHODS: A multicenter retrospective cohort study was performed in patients who were diagnosed with early pregnancy loss (< or =13 gestational weeks) and examined for fetal karyotype at the CHA Gangnam Medical Center, CHA Bundang Medical Center, and CHA Gumi Medical Center between January 2011 and December 2012. Karyotyping was performed by the Genetic Laboratory of the Fertility Center of CHA Gangnam Medical Center. Medical records were reviewed for demographics, karyotype analysis and hormonal assay of ovarian reserve including antimullerian hormone (AMH) and follicle stimulating hormone. Statistical analysis was performed using SPSS software. RESULTS: A total 462 patients were included in this study. The mean age of the patients was 35.31+/-4.12 years and the mean AMH level was 3.88+/-3.50 ng/mL (n=195). Two hundred eleven conceptuses (45.7%) of patients showed the euploid and 251 (54.3%) showed the aneuploid. There are significant differences in maternal age, AMH and gestational age between fetal euploid and aneuploid groups (34.46+/-4.35 vs. 36.04+/-3.78 years, P<0.001; 4.60+/-3.86 vs. 3.43+/-3.18 ng/mL, P=0.022; 7.67+/-1.54 vs. 8.27+/-1.46 weeks, P<0.001, respectively). Multivariate analysis revealed that low AMH level and early gestational age were maternal age-independent markers for fetal aneuploid (P<0.001 and P=0.045, respectively). CONCLUSION: Low maternal AMH level might be a predicting marker for fetal aneuploid in early pregnancy loss.
