Inherited thrombophilia profile in patients with recurrent miscarriages: Experience from a tertiary care center in north India.
10.5468/ogs.2015.58.6.514
- Author:
Narender KUMAR
1
;
Jasmina AHLUWALIA
;
Reena DAS
;
Meenakshi ROHILLA
;
Sunil BOSE
;
Hari KISHAN
;
Neelam VARMA
Author Information
1. Department of Hematology, Postgraduate Institute of Medical Education & Research, Chandigarh, India. nkkalson@yahoo.co.in
- Publication Type:Original Article
- Keywords:
Abortion, habitual;
Factor V Leiden;
Protein S;
Thrombophilia
- MeSH:
Abortion, Habitual*;
Antithrombin III;
Factor V;
Female;
Humans;
India*;
Pregnancy;
Protein S;
Tertiary Care Centers*;
Tertiary Healthcare*;
Thrombophilia*
- From:Obstetrics & Gynecology Science
2015;58(6):514-517
- CountryRepublic of Korea
- Language:English
-
Abstract:
The cause of recurrent miscarriage (RM) remains unexplained in approximately 30% to 50% cases. The association of inherited thrombotic factors and RM patients has not been documented from the northern part of India. A total of 40 patients had been investigated for inherited thrombophilia workup (protein C, protein S [PS], antithrombin III, and factor V Leiden [FVL] mutation) over a period of 10 years (2005 to 2014). RM patients were divided in to three groups. Group I (only 1st trimester loss), group II (only 2nd and 3rd trimester), and group III (mixed). Each group comprised of the following numbers of patients respectively: I, 24; II, 2; III, 14. Heterozygous FVL mutation was found in 10% (4/40) cases. PS deficiency was detected in 2.7% (1/37) cases. In the present study FVL and PS were seems to be associated with a subset of patients however further studies with larger numbers of patients are recommended for better evaluation.
