Antimicrobial and Antitumor Photodynamic Effects of Phleichrome from the Phytopathogenic Fungus Cladosporium Phlei.
10.1080/12298093.2018.1551599
- Author:
Kum Kang SO
1
;
Jeesun CHUN
;
Dae Hyuk KIM
Author Information
1. Departments of Molecular Biology and Bioactive Material Sciences, Institute for Molecular Biology and Genetics Chonbuk National University, Jeonju, Jeollabuk-do, Korea. dhkim@jbnu.ac.kr
- Publication Type:Note
- Keywords:
Phleichrome;
perelenequinone;
photodynamic bactericidal activity;
photodynamic antitumor activity
- MeSH:
Cell Line;
Cell Line, Tumor;
Cladosporium*;
Diffusion;
Fungi*;
Gram-Positive Bacteria;
Humans;
In Vitro Techniques;
Methods;
Photochemotherapy;
Photosensitizing Agents
- From:Mycobiology
2018;46(4):448-451
- CountryRepublic of Korea
- Language:English
-
Abstract:
Fungal perylenequinones have photodynamic activity and are promising photosensitizers for photodynamic therapy (PDT). Here, we investigated the bactericidal and antitumor activities of phleichrome from the fungal perylenequinone family in vitro. Photodynamic bactericidal activity of phleichrome was analyzed by agar-well diffusion method under dark and illuminated conditions. The photodynamic antitumor activity of phleichrome was analyzed in MCF-7, HeLa, SW480, and HepG2 human cancer cell lines using in vitro cytotoxicity assays. Photodynamic bactericidal activities against Gram-negative and Gram-positive bacteria were species-specific. Antitumor activity against all tumor cell lines increased under the illuminated condition. Depending on the results of the analyses, Phleichrome has potential for further drug development related to its antibacterial and antitumor activities.
