Screening and Optimal Extraction of a New Antidementia beta-Secretase Inhibitor-Containing Mushroom.
10.4489/MYCO.2008.36.3.195
- Author:
Dong Soo SEO
1
;
Eun Na LEE
;
Geon Sik SEO
;
Jong Soo LEE
Author Information
1. Department of Life Science and Genetic Engineering, Paichai University, Daejeon 302-735, Korea. biotech8@pcu.ac.kr
- Publication Type:Brief Communication
- Keywords:
Antidementia;
BACE1;
beta-Secretase inhibitor;
Lentinula edodes
- MeSH:
Agaricales;
Amyloid Precursor Protein Secretases;
Fruit;
Mass Screening;
Methanol;
Shiitake Mushrooms
- From:Mycobiology
2008;36(3):195-197
- CountryRepublic of Korea
- Language:English
-
Abstract:
To produce a potent antidementia beta-secretase inhibitor from a mushroom, the beta-secretase inhibitory activities of various mushroom extracts were determined. Methanol extracts of Lentinula edodes exhibited the highest inhibitory activity (40.1%). The inhibitor was maximally extracted when a fruiting body of L. edodes was treated with 50% methanol at 40degrees C for 24 h.
