Extraction and Characteristics of Anti-obesity Lipase Inhibitor from Phellinus linteus.
- Author:
Jong Kug LEE
1
;
Jeong Hoon JANG
;
Jong Tae LEE
;
Jong Soo LEE
Author Information
1. Chungnam Agricultural Research and Extension Services, Yesan 340-861, Korea.
- Publication Type:Original Article
- Keywords:
Anti-obesity;
Lipase inhibitor;
Phellinus linteus
- MeSH:
Acetylcholinesterase;
Agaricales;
Fruit;
Hydrogen-Ion Concentration;
Lipase;
Methanol;
Superoxides
- From:Mycobiology
2010;38(1):52-57
- CountryRepublic of Korea
- Language:English
-
Abstract:
To develop a potent anti-obesity lipase inhibitor from mushroom, the lipase inhibitory activities of various mushroom extracts were determined. Methanol extracts from Phellinus linteus fruiting body exhibited the highest lipase inhibitory activity (72.8%). The inhibitor was maximally extracted by treatment of a P. linteus fruiting body with 80% methanol at 40degrees C for 24 hr. After partial purification by systematic solvent extraction, the inhibitor was stable in the range of 40~80degrees C and pH 2.0~9.0. In addition to lipase inhibitory activity, the inhibitor showed 59.4% of superoxide dismutase-like activity and 56.3% of acetylcholinesterase inhibitory activity.
