Appraisal of Antihyperlipidemic Activities of Lentinus lepideus in Hypercholesterolemic Rats.
- Author:
Ki Nam YOON
1
;
Jae Seong LEE
;
Hye Young KIM
;
Kyung Rim LEE
;
Pyung Gyun SHIN
;
Jong Chun CHEONG
;
Young Bok YOO
;
Nuhu ALAM
;
Tai Moon HA
;
Tae Soo LEE
Author Information
1. Division of Life Sciences, University of Incheon, Incheon 406-840, Korea. tslee@incheon.ac.kr
- Publication Type:Original Article
- Keywords:
Agarose gel electrophoresis;
Antihyperlipidemic;
Atherogenic lipid profile;
Histopathology;
Hypercholesterolemic rats;
Lentinus lepideus
- MeSH:
Agaricales;
Animals;
Azo Compounds;
Body Weight;
Cholesterol;
Diet;
Electrophoresis, Agar Gel;
Feces;
Female;
Fruit;
Hepatocytes;
Humans;
Insurance Benefits;
Korea;
Lentinula;
Lipoproteins;
Liver;
Phospholipids;
Plasma;
Rats
- From:Mycobiology
2011;39(4):283-289
- CountryRepublic of Korea
- Language:English
-
Abstract:
The wild edible mushroom, Lentinus lepideus has recently been cultivated for commercial use in Korea. While the mushroom has been widely used for nutritional and medicinal purposes, the possible anti-hyperlipidemic action is unclear. The effects of dietary L. lepideus on plasma and feces biochemical and on the liver histological status were investigated in hypercholesterolemic rats. Six-wk-old female Sprague-Dawley albino rats were divided into three groups of 10 rats each. Biochemical and histological examinations were performed. A diet containing 5% L. lepideus fruiting bodies reduced plasma total cholesterol, triglyceride, low-density lipoprotein, total lipid, phospholipids, and the ratio of low-density to high-density lipoprotein. Body weight was reduced. The diet did not adversely affect plasma biochemical and enzyme profiles. L. lepideus reduced significantly plasma beta- and pre-beta-lipoprotein, while alpha-lipoprotein content was increased. A histological study of hepatic cells by conventional hematoxylin-eosin and oil red O staining revealed normal findings for mushroom-fed hypercholesterolemic rats. The present study suggests that a diet supplemented with L. lepideus can provide health benefits by acting on the atherogenic lipid profile in hypercholesterolemic rats.
