Spectral CT: Preliminary Studies in the Liver Cirrhosis.
10.3348/kjr.2012.13.4.434
- Author:
Peijie LV
1
;
Xiaozhu LIN
;
Jianbo GAO
;
Kemin CHEN
Author Information
1. Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Henan Province 450052, China.
- Publication Type:Original Article
- Keywords:
Spectral CT;
Dual-energy CT;
Liver cirrhosis;
Iodine concentration;
Material decomposition
- MeSH:
Analysis of Variance;
Case-Control Studies;
Contrast Media/diagnostic use;
Female;
Humans;
Liver/pathology;
Liver Cirrhosis/pathology/*radiography;
Male;
Middle Aged;
Prospective Studies;
ROC Curve;
Sensitivity and Specificity;
Tomography, X-Ray Computed/*methods;
Triiodobenzoic Acids/diagnostic use
- From:Korean Journal of Radiology
2012;13(4):434-442
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To investigate the value of spectral CT imaging in the diagnosis and classification of liver cirrhosis during the arterial phase (AP) and portal venous phase (PVP). MATERIALS AND METHODS: Thirty-eight patients with liver cirrhosis (Child-Pugh class A/B/C: n = 10/14/14), and 43 patients with healthy livers, participated in this study. The researchers used abdominal spectral CT imaging during AP and PVP. Iodine concentration, derived from the iodine-based material-decomposition image and the iodine concentration ratio (ICratio) between AP and PVP, were obtained. Statistical analyses {two-sample t test, One-factor analysis of variance, and area under the receiver operating characteristic curve (A [z])} were performed. RESULTS: The mean normalized iodine concentration (NIC) (0.5 +/- 0.12) during PVP in the control group was significantly higher than that in the study group (0.4 +/- 0.10 on average, 0.4 +/- 0.08 for Class A, 0.4 +/- 0.15 for Class B, and 0.4 +/- 0.06 for Class C) (All p < 0.05). Within the cirrhotic liver group, the mean NIC for Class C during the AP (0.1 +/- 0.05) was significantly higher than NICs for Classes A (0.1 +/- 0.06) and B (0.1 +/- 0.03) (Both p < 0.05). The ICratio in the study group (0.4 +/- 0.15), especially for Class C (0.5 +/- 0.14), was higher than that in the control group (0.3 +/- 0.15) (p < 0.05).The combination of NIC and ICratio showed high sensitivity and specificity for differentiating healthy liver from cirrhotic liver, especially in Class C cirrhotic liver. CONCLUSION: Spectral CT Provides a quantitative method with which to analyze the cirrhotic liver, and shows the potential value in the classification of liver cirrhosis.
