Cytotoxicity of Paecilomyces tenuipes Against Human Carcinoma Cells, HepG2 and MCF-7 In Vitro.
- Author:
Joong Sup SHIM
1
;
Hae Ryong CHANG
;
Eung Gi MIN
;
Yong Hae KIM
;
Yeong Hwan HAN
Author Information
1. Department of Biology, College of Natural Science, Dongguk University, Gyeongju 780-714, Korea. yhhan@dongguk.ac.kr
- Publication Type:In Vitro ; Brief Communication
- Keywords:
Cytotoxicity;
Fruiting body;
Paecilomyces tenuipes
- MeSH:
Chloroform;
Fruit;
Hep G2 Cells*;
Humans*;
Inhibitory Concentration 50;
Methanol;
Paecilomyces*;
Solvents
- From:Mycobiology
2001;29(3):170-172
- CountryRepublic of Korea
- Language:English
-
Abstract:
The methanolic extract of fruiting body of Paecilomyces tenuipes DGUM 32001 showed significant cytotoxicity against human cancer cells: HepG2 and MCF-7. The methanolic extract was further fractionated with organic solvents such as chloroform and ethyl acetate in that order. Among the fractions tested, the ethyl acetate fraction showed the highest cytotoxicity against the carcinoma tested. The IC50 values of ethyl acetate fraction against HepG and MCF-7 were 40 and 9.6 microg/ml, respectively.
