Anti-cancer Activities of Ginseng Extract Fermented with Phellinus linteus.
10.4489/MYCO.2009.37.1.021
- Author:
Jong Jin LEE
1
;
Ho Kyun KWON
;
In Ho JUNG
;
Yong Baik CHO
;
Kyu Joong KIM
;
Jong Lae KIM
Author Information
1. Department of Bioscience & Biotechnology, Central Research Center, Whanin Pharm. Co., Ltd., Suwon 443-766, Korea. kimjl@whanin.com
- Publication Type:In Vitro ; Original Article
- Keywords:
Antitumor activity;
Ginsenoside Rg3;
HUVEC;
Phellinus linteus
- MeSH:
Animals;
Cell Line;
Fermentation;
Ginsenosides;
Humans;
Lung;
Mice;
Nitric Oxide;
Panax
- From:Mycobiology
2009;37(1):21-27
- CountryRepublic of Korea
- Language:English
-
Abstract:
In the present study, the anti-cancer effects of ginseng fermented with Phellinus linteus (GFPL) extract were examined through in vitro and in vivo assays. GFPL was produced by co-cultivating ginseng and Phellinus linteus together. Ginsenoside Rg3, Rh1 and Rh2 are important mediators of anti-angiogenesis and their levels in GFPL were enriched 24, 19 and 16 times, respectively, more than that of ginseng itself through the fermentation. GFPL exhibited distinct anti-cancer effects, including growth inhibition of the human lung carcinoma cell line A549, and promotion of immune activation by stimulating nitric oxide (NO) production in Raw 264.7 cells. Further evidence supporting anti-cancer effects of GFPL was its significant prolongment of the survival of B16F10 cancer cell-implanted mice. These results suggest that the GFPL may be a candidate for cancer prevention and treatment through immune activation and anti-angiogenic effects by enriching Rg3, Rh1 and Rh2.
