Epidemiological Comparison of viral hepatitis-hepatocellular carcinoma(HCC) and non viral hepatitis-hepatocellular carcinoma(HCC).
- Author:
Pae Gun PARK
1
;
Song Gyu YOON
;
Hee Sup LEE
;
Jin Kun JANG
;
Ju Hee MAENG
;
Gee Hyun LEE
;
Jong Soo CHOI
Author Information
1. Department of Internal Medicine, Gangneung Asan Hospital College of Medicine. Ulsan University. r000040@freechal.com
- Publication Type:Original Article
- Keywords:
Viral hepatitis;
Hepatocellular carcinoma;
Non B,C-hepatocellular carcinoma
- MeSH:
Alcohol Drinking;
Alcoholism;
Carcinoma, Hepatocellular;
Diagnosis;
Fibrinogen;
Hepatitis;
Hepatitis B Surface Antigens;
Hepatitis B virus;
Humans;
Incidence;
Korea;
Liver Cirrhosis;
Liver Diseases;
Occupations;
Vaccination
- From:Korean Journal of Epidemiology
2003;25(1):32-38
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Korea is one of high incidence areas of Hepatocellular carcinoma (HCC) and major etiologic factor is hepatitis B virus (HBV). In future incidence of HBV related HCC may decrease and non viral hepatitis HCC (Non-B,C HCC) relatively increase because of widely used vaccination for HBV. To evaluate epidemiological characters of Non-B,C HCC, We divided HCC by viral or non-viral feature and compared each others. METHODS: 185 patients firstly diagnosed HCC and 455 normal subjects included from January 1997 to December 2000 and divided into 3 groups, HBV group (positive HBsAg), HCV group (positive anti-HCV Ab) and Non-B,C group (both negative HBsAg and anti-HCV Ab). RESULTS: 136 cases were HBV group (73.5%), 19 cases were HCV group (10.3%) and 27 cases were Non-B,C group (14.6%). Mean age of Non-B,C group at diagnosis was higher than HBV group (64.1+/-7.1 vs 55.6+/-7.7). Non-B,C HCC were more associated with alcohol abuse and rural residence (p<0.01). There was no difference of family history of liver disease, coexistence rate of liver cirrhosis and occupation. CONCLUSION: Non-B,C HCC tended to be older in mean age than HBV HCC and more associated with alcohol abuse and rural residence. This characteristics of Non-B,C HCC supposed to be from difference in alcohol consumption and environment.
