The Association between Helicobacter pylori Infection and Gastric Adenocarcinoma: a Review of the Literature.
- Author:
So Young OH
1
;
Aesun SHIN
;
Seung Sik HWANG
;
Keun Young YOO
Author Information
1. Department of Preventive Medicine, Ewha Woman's University College of Medicine, Korea.
- Publication Type:Review
- Keywords:
stomach neoplasms;
Helicobacter pylori
- MeSH:
Adenocarcinoma*;
Animal Experimentation;
Gastritis;
Helicobacter pylori*;
Helicobacter*;
Humans;
Korea;
Meta-Analysis as Topic;
Stomach Neoplasms
- From:Korean Journal of Epidemiology
2002;24(2):93-106
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Stomach cancer is a major cancer in the world as well as in Korea. Helicobacter pylori infection was suggested causing atropic gastritis, but there has been a debate on the association with the gastric adenocarcinoma. We reviewed recent literatures and meta-analyses on the association between Helicobacter pylori infection and the development of gastric adenocarcinoma. PESULTS: The animal experiments suggested that Helicobacter pylori is a causative agent of gastric adenocarcinoma. Meta-analyses on the relationship between Helicobacter pylori infection and gastric adenocarcinoma showed increased risk in infected person, but the strength of association was varied with study design, characteristics of study participants and the nature of tumors. CONCLUSIONS: Recent study results suggested that Helicobacter pylori is a necessary causative agent for development of gastric adenocarcinoma. Assessment of the association between Helicobacter pylori infection and other factors related with gastric cancer risks and the effects of the eradication therapy of Helicobacter pylori infection on the prevention of gastvic cancer need further evaluation.
