Renal Tubular Acidosis in Cadmium-Intoxicated Rats.
- Author:
Do Whan AHN
1
;
Kyoung Ryong KIM
;
Jang Kyu CHOI
;
Yang Saeng PARK
Author Information
1. Department of Physiology, Kosin University College of Medicine, Busan, Korea. yspark @ns.kosinmed.or.kr
- Publication Type:Original Article
- Keywords:
Cadmium;
Kidney;
Acid-base
- MeSH:
Acidosis;
Acidosis, Renal Tubular*;
Adult;
Ammonium Compounds;
Animals;
Cadmium;
Cadmium Chloride;
Humans;
Hydrogen-Ion Concentration;
Injections, Subcutaneous;
Ion Transport;
Kidney;
Male;
Membranes;
Plasma;
Rats*;
Rats, Sprague-Dawley
- From:The Korean Journal of Physiology and Pharmacology
2002;6(1):41-46
- CountryRepublic of Korea
- Language:English
-
Abstract:
Effect of cadmium (Cd) intoxication on renal acid-base regulation was studied in adult male Sprague-Dawley rats. Cd intoxication was induced by subcutaneous injections of CdCl2 at a dose of 2 mg Cd/kg/day for 3-4 weeks. In Cd-intoxicated animals, arterial pH, PCO2 and plasma bicarbonate concentration decreased, showing a metabolic acidosis. Urine pH and urinary bicarbonate excretion increased and titratable acid excretion decreased with no change in ammonium excretion. In renal cortical brush-border membrane vesicles derived from Cd-exposed animals, the Na /H antiporter activity was significantly attenuated. These results indicate that chronic exposures to Cd impair the proximal tubular mechanism for H secretion (i.e., Na /H antiport), leading to a metabolic acidosis.
