Taurine relaxes human radial artery through potassium channel opening action.
10.4196/kjpp.2017.21.6.617
- Author:
Kemal Gokhan ULUSOY
1
;
Erkan KAYA
;
Kubilay KARABACAK
;
Melik SEYREK
;
Ibrahim DUVAN
;
Vedat YILDIRIM
;
Oguzhan YILDIZ
Author Information
1. Department of Medical Pharmacology, Gulhane Faculty of Medicine, University of Health Sciences, Ankara 06018, Turkey. oguzhany01@gmail.com
- Publication Type:Original Article
- Keywords:
Potassium Channel;
Radial Artery;
Taurine;
Vasodilation
- MeSH:
4-Aminopyridine;
Baths;
Calcium;
Calcium Chloride;
Glyburide;
Humans*;
Potassium Channels*;
Potassium Chloride;
Potassium*;
Radial Artery*;
Relaxation;
Serotonin;
Taurine*;
Tetraethylammonium;
Vasodilation
- From:The Korean Journal of Physiology and Pharmacology
2017;21(6):617-623
- CountryRepublic of Korea
- Language:English
-
Abstract:
The vascular actions and mechanisms of taurine were investigated in the isolated human radial artery (RA). RA rings were suspended in isolated organ baths and tension was recorded isometrically. First, a precontraction was achieved by adding potassium chloride (KCl, 45 mM) or serotonin (5-hydroxytryptamine, 5-HT, 30 µM) to organ baths. When the precontractions were stable, taurine (20, 40, 80 mM) was added cumulatively. Antagonistic effect of taurine on calcium chloride (10 µM to 10 mM)-induced contractions was investigated. Taurine-induced relaxations were also tested in the presence of the K⁺ channel inhibitors tetraethylammonium (1 mM), glibenclamide (10 µM) and 4-aminopyridine (1 mM). Taurine did not affect the basal tone but inhibited the contraction induced by 5-HT and KCl. Calcium chloride-induced contractions were significantly inhibited in the presence of taurine (20, 40, 80 mM) (p<0.05). The relaxation to taurine was inhibited by tetraethylammonium (p<0.05). However, glibenclamide and 4-aminopyridine did not affect taurine-induced relaxations. Present experiments show that taurine inhibits 5-HT and KCl-induced contractions in RA, and suggest that large conductance Ca²⁺-activated K⁺ channels may be involved in taurine-induced relaxation of RA.
