Effects of Ambroxol, S-carboxymethylcysteine, Dextromethorphan and Noscapine on Mucin Release from Airway Goblet Cells.
- Author:
Ho Jin HEO
1
;
Hyun Jae LEE
;
Chi Soon YOON
;
Seung Pyong LIM
;
Jeong Ho SEOK
;
Un Kyo SEO
;
Choong Jae LEE
Author Information
1. Department of Pharmacology, College of Medicine, Chungnam National University, Daejeon 301-131, Korea. LCJ123@cnu.ac.kr
- Publication Type:Original Article
- Keywords:
Airway;
Mucin;
Ambroxol;
S-carboxymethyl-L-cysteine;
Dextromethorphan;
Noscapine
- MeSH:
Ambroxol*;
Animals;
Carbocysteine*;
Cricetinae;
Dextromethorphan*;
Epithelial Cells;
Goblet Cells*;
Mucins*;
Noscapine*
- From:The Korean Journal of Physiology and Pharmacology
2005;9(6):323-326
- CountryRepublic of Korea
- Language:English
-
Abstract:
In the present study, we investigated whether ambroxol, S-carboxymethyl-L-cysteine, dextromethorphan and noscapine affect mucin release from airway goblet cells. Confluent primary hamster tracheal surface epithelial cells were metabolically radiolabeled and chased for 30 min in the presence of varying concentrations of the above agents to assess the effects on 3H-mucin release. Noscapine stimulated mucin release during 30 min of treatment period in a dose-dependent manner. However, ambroxol, S-carboxymethyl-L-cysteine and dextromethorphan showed no significant effect on mucin release during 30 min of treatment period. We conclude that noscapine can affect mucin release by acting on airway mucin-secreting cells.
