Altered renal nitric oxide system in experimental hypertensive rats.
- Author:
Eun Suk YANG
1
,
2
;
Jongun KANG
;
Dae Gill LEE
Author Information
1. Department of Physiology, Chonnam University Medical School
2. Hormone Research Center, Chonnam National University, Kwanaiu 501-190, South Korea.
- Publication Type:Original Article
- Keywords:
Kidney;
Nitric oxide synthases;
Nitrite contents;
Deoxycorticosterone acetate-salt hypertension;
Two-kidney;
One clip hypertension
- MeSH:
Animals;
Blotting, Western;
Desoxycorticosterone;
Hypertension;
Kidney;
Nitric Oxide*;
Nitrites;
Protein Isoforms;
Rats*
- From:The Korean Journal of Physiology and Pharmacology
1998;2(4):455-460
- CountryRepublic of Korea
- Language:English
-
Abstract:
The present study was aimed at investigating whether the development of hypertension is related with an altered expression of nitric oxide synthases (NOS) in the kidney. By Western blot analysis, the expression of bNOS and ecNOS isoforms was determined in the kidney of deoxycorticosterone acetate (DOCA)-salt and two-kidney, one clip (2K1C) rats. In DOCA-salt hypertension, the expression of both bNOS and ecNOS was decreased, along with tissue contents of nitrites. In 2K1C hypertension, the nitrite content of the clipped kidney was decreased along with ecNOS levels, whereas neither the nitrite content nor the expression of NOS isoforms was significantly altered in the contralateral non-clipped kidney. These results suggest that the development of hypertension is associated with an altered renal expression of NOS and nitric oxide generation in DOCA-salt and 2K1C rats.
