Postprandial Colonic Motor Activity in Patients with Irritable Bowel Syndrome.
- Author:
Ji Bong JEONG
1
;
Youg Mo YANG
;
Won Joong JEON
;
Jeong Chul SEO
;
Hyun Hee LEE
;
Byeong Seong KO
;
Hee Bok CHAE
;
Seon Mee PARK
;
Sei Jin YOUN
Author Information
1. Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea.
- Publication Type:Original Article
- Keywords:
Irritable bowel syndrome;
Motility Index(MI);
Colonic manometry
- MeSH:
Catheters;
Colon*;
Colon, Descending;
Colon, Sigmoid;
Humans;
Irritable Bowel Syndrome*;
Meals;
Motor Activity*
- From:Korean Journal of Gastrointestinal Motility
2000;6(1):20-30
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: The purpose of this study was to discover the physiologic difference of a postprandial motor response in different segments of the colon between patients with irritable bowel syndrome and healthy subjects. METHODS: Irritable bowel syndrome patients are categorized into three groups according to their main symptoms; loose stool-dominant (A, n=5), abdominal pain-dominant (B, n=5), constipation-dominant (C, n=6) and the normal control group (n=5). The intraluminal pressure activity was measured with a colonoscopically positioned multilumen manometric catheter. The change of the colonic motility index (MI) is presented as a percent change (mean+/-SE%) over the basal period in response to a meal. RESULTS: 1) In the transverse, descending and sigmoid colon of healthy subjects, the percentage changes in the basal MI during the first 30 min after the meal are significantly increased (p < 0.05-0.01). 2) In the sigmoid colon, the percentage changes in the basal MI during the first 30 min after the meal were 62+/-18 in A, 29+/-18 in B, 12+/-8 in C and 306+/-102% in heathy subjects respectively, which shows a significant difference between the MI of control and healthy subjects (p < 0.05). 3) In B and C, the percentage changes in the basal MI during the first 30 min after the meal in the descending colon were 105+/-38, 11+/-7, respectively, which shows a significant difference between the two groups (p < 0.05). In A and C, the percentage changes in the basal MI during the first 30 min after the meal in the sigmoid colon was 62+/-18, 12+/-8, respectively, which shows a significant change between the two groups (p < 0.05). CONCLUSION: This study suggests that postprandial intraluminal pressure differences play a role in the pathophysiology of irritable bowel syndrome.
