Short-term Treatment of Daumone Improves Hepatic Inflammation in Aged Mice.
10.4196/kjpp.2015.19.3.269
- Author:
Jong Hee PARK
1
;
Hunjoo HA
Author Information
1. Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea. hha@ewha.ac.kr
- Publication Type:Original Article
- Keywords:
Aging;
Hep G2 cells;
Inflammation;
Liver;
Pheromones
- MeSH:
Administration, Oral;
Aging;
Animals;
Caenorhabditis elegans;
Child, Preschool;
Cytokines;
Gene Expression;
Hep G2 Cells;
Humans;
Inflammation*;
Liver;
Macrophages;
Male;
Mice*;
NF-kappa B;
Pheromones;
Phosphorylation;
Tumor Necrosis Factor-alpha
- From:The Korean Journal of Physiology and Pharmacology
2015;19(3):269-274
- CountryRepublic of Korea
- Language:English
-
Abstract:
Chronic inflammation has been proposed as one of the main molecular mechanisms of aging and age-related diseases. Although evidence in humans is limited, short-term calorie restriction (CR) has been shown to have anti-inflammatory effects in aged experimental animals. We reported on the long-term treatment of daumone, a synthetic pheromone secreted by Caenorhabditis elegans in an energy deficient environment, extends the life-span and attenuates liver injury in aged mice. The present study examined whether late onset short-term treatment of daumone exerts anti-inflammatory effects in the livers of aged mice. Daumone was administered orally at doses of 2 or 20 mg/kg/day for 5 weeks to 24-month-old male C57BL/6J mice. Increased liver macrophage infiltration and gene expression of proinflammatory cytokines in aged mice were significantly attenuated by daumone treatment, suggesting that short-term oral administration of daumone may have hepatoprotective effects. Daumone also dose-dependently suppressed tumor necrosis factor-alpha (TNF-alpha)-induced nuclear factor-kappaB (NF-kappaB) phosphorylation in HepG2 cells. The present data demonstrated that short-term treatment of daumone has anti-inflammatory effects in aged mouse livers possibly through suppression of NF-kappaB signaling and suggest that daumone may become a lead compound targeting aging and age-associated diseases.
