Decreased Expression of PTEN in Olfactory Bulb of Rat Pub after Naris Closure.
- Author:
Jaeyoung CHO
1
;
Sang Hyun LEE
;
Geon Hee LEE
;
Wanjoo CHUN
;
Yee Tae PARK
;
So Young LIM
;
Sung Soo KIM
Author Information
1. Department of Pharmacology, College of Medicine, Medical Science Research Institute, Kangwon National University, Chunchon 200-701, Korea. ksslsy@kangwon.ac.kr
- Publication Type:Original Article
- Keywords:
PTEN (phosphatase and tensin homolog);
Olfactory bulb;
Naris closure
- MeSH:
Animals;
Central Nervous System;
Clone Cells;
Glioma;
Odors;
Olfactory Bulb*;
Rats*;
Sensory Deprivation
- From:The Korean Journal of Physiology and Pharmacology
2004;8(1):17-20
- CountryRepublic of Korea
- Language:English
-
Abstract:
PTEN (phosphatase and tensin homolog) is a dual specific phosphatase antagonizing phosphoinositide 3-kinase activity, and has first been cloned as a tumor suppressor for glioma. Although the role of PTEN as a tumor suppressor has been well studied, little is known about signaling mechanisms regulating expression and/or activity of PTEN in the central nervous system. In this study, we investigated whether PTEN expression is regulated by sensory deprivation. P5 rat pups were unilaterally naris-closed, and olfactory bulbs were immunohistochemically analyzed with PTEN antibody at the 7th day after naris closure. PTEN immunoreactivity was found to be down-regulated in both glomerular, external plexiform and subependymal cell layers, suggesting that odor deprivation signals down-regulate expression of PTEN in the olfactory bulb. To the best of our knowledge, this is the first report to suggest that PTEN expression is regulated by sensory deprivation signals in neonatal rats.
