Pharmacokinetics of Dehydroevodiamine Following Intravenous Administration in Rats.
- Author:
Seong Yun KIM
1
;
Chan Soo MOON
;
Yun Sik CHOI
;
Sang Bok LEE
Author Information
1. Department of Pharmacology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea. sbl@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Dehydroevodiamine;
Pharmacokinetics;
Wu-chu-yu;
HPLC;
Intravenous injection;
Rats
- MeSH:
Administration, Intravenous*;
Animals;
Asian Continental Ancestry Group;
Chromatography, High Pressure Liquid;
Chromatography, Liquid;
Half-Life;
Herbal Medicine;
Humans;
Injections, Intravenous;
Kinetics;
Pharmacokinetics*;
Plasma;
Rats*
- From:The Korean Journal of Physiology and Pharmacology
2004;8(1):65-67
- CountryRepublic of Korea
- Language:English
-
Abstract:
Dehydroevodiamine (DHED) is one of the bioactive components of the Chinese herbal medicine Wu-chu-yu-tang that has been shown to produce various pharmacological effects. In the present study, we investigated the pharmacokinetics of DHED after intravenous administration of two doses (2.5 and 5 mg/kg) in anesthetized rats. The plasma concentration of DHED was measured by reverse-phase high-performance liquid chromatography with UV detection. The mean area under the curve of the time-concentration profile was 21.9 and 53.9 microgram-min/ml after the 2.5- and 5-mg/kg doses, respectively, and the volume of distribution was 1584.9 and 1580.6 ml following 2.5- and 5-mg/kg doses, respectively. Plasma concentration profiles versus time were compatible with a two-compartment model and first-order kinetics. The terminal elimination half-life was 91.8+/-16.6 min and 78.7+/-11.9 min in the dose of 2.5 and 5 mg/kg, respectively. This is the first report to study the pharmacokinetics of DHED in animals.
