Chronic Non-Social Stress Affects Depressive Behaviors But Not Anxiety in Mice.
10.4196/kjpp.2014.18.3.263
- Author:
Sang Ho YOON
1
;
Byung Hak KIM
;
Sang Kyu YE
;
Myoung Hwan KIM
Author Information
1. Department of Physiology, Seoul National University College of Medicine, Seoul 110-799, Korea. kmhwany@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Anxiety;
Chronic non-social stress;
Depression;
Open field test;
Tail suspension test
- MeSH:
Animals;
Anxiety*;
Brain;
Depression;
Hindlimb Suspension;
Humans;
Mice*;
Phenotype;
Risk Factors;
Rodentia;
Social Isolation
- From:The Korean Journal of Physiology and Pharmacology
2014;18(3):263-268
- CountryRepublic of Korea
- Language:English
-
Abstract:
The etiology of most psychiatric disorders is still incompletely understood. However, growing evidence suggests that stress is a potent environmental risk factor for depression and anxiety. In rodents, various stress paradigms have been developed, but psychosocial stress paradigms have received more attention than non-social stress paradigms because psychosocial stress is more prevalent in humans. Interestingly, some recent studies suggest that chronic psychosocial stress and social isolation affects mainly anxiety-related behaviors in mice. However, it is unclear whether chronic non-social stress induces both depression- and anxiety-related phenotypes or induces one specific phenotype in mice. In the present study, we examined the behavioral consequences of three chronic non-social stress paradigms: chronic predictable (restraint) stress (CPS), chronic unpredictable stress (CUS), and repeated corticosterone-HBC complex injection (RCI). Each of the three paradigms induced mild to severe depression/despair-like behaviors in mice and resulted in increased immobility in a tail suspension test. However, anxiety-related phenotypes, thigmotaxis and explorative behaviors, were not changed by the three paradigms. These results suggest that depression- and anxiety-related phenotypes can be dissociated in mouse stress models and that social and non-social stressors might affect brain circuits and behaviors differently.
