The Effects of Eupatilin (Stillen(R)) on Motility of Human Lower Gastrointestinal Tracts.
10.4196/kjpp.2014.18.5.383
- Author:
Seung Bum RYOO
1
;
Heung Kwon OH
;
Sung A YU
;
Sang Hui MOON
;
Eun Kyung CHOE
;
Tae Young OH
;
Kyu Joo PARK
Author Information
1. Division of Colorectal Surgery, Department of Surgery, Seoul National University College of Medicine, Seoul 110-744, Korea. kjparkmd@plaza.snu.ac.kr
- Publication Type:Original Article
- Keywords:
Colon;
Eupatilin;
Ileum;
Motility;
Smooth muscle
- MeSH:
Area Under Curve;
Colon;
Cytokines;
Gastritis;
Gastrointestinal Motility;
Humans;
Ileum;
Lower Gastrointestinal Tract*;
Membrane Potentials;
Microelectrodes;
Muscle Cells;
Muscle, Smooth;
Myoelectric Complex, Migrating;
Neuropeptides;
Oxygen;
Peptic Ulcer
- From:The Korean Journal of Physiology and Pharmacology
2014;18(5):383-390
- CountryRepublic of Korea
- Language:English
-
Abstract:
Gastrointestinal motility consists of phasic slow-wave contractions and the migrating motor complex (MMC). Eupatilin (Stillen(R)) has been widely used to treat gastritis and peptic ulcers, and various cytokines and neuropeptides are thought to be involved, which can affect gastrointestinal motility. We performed a study to identify the effects of eupatilin on lower gastrointestinal motility with electromechanical recordings of smooth muscles in the human ileum and colon. Ileum and colon samples were obtained from patients undergoing bowel resection. The tissues were immediately stored in oxygenated Krebs-Ringer's bicarbonate solution, and conventional microelectrode recordings from muscle cells and tension recordings from muscle strips and ileal or colonic segments were performed. Eupatilin was perfused into the tissue chamber, and changes in membrane potentials and contractions were measured. Hyperpolarization of resting membrane potential (RMP) was observed after administration of eupatilin. The amplitude, AUC, and frequency of tension recordings from circular and longitudinal smooth muscle strips and bowel segments of the ileum and colon were significantly decreased after admission of eupatilin. Eupatilin elicited dose-dependent decreases during segmental tension recordings. In conclusion, eupatilin (Stillen(R)) showed inhibitory effects on the human ileum and colon. We propose that this drug may be useful for treating diseases that increase bowel motility, but further studies are necessary.
