Autonomic Neural Regulation of Sodium Transporters and Water Channels in Rat Submandibular Gland.
- Author:
Sun Yeol RYU
1
;
Hyun JUNG
;
Ki Yung KIM
;
Miwon KIM
;
Jong Un LEE
Author Information
1. Department of Oromaxillofacial Surgery, Chonnam National University Dental School, Gwangju, Korea.
- Publication Type:Original Article
- Keywords:
Sympathetic;
Parasympathetic;
Na,K-ATPase;
Epithelial sodium channels;
Aquaporin water channels;
Submandibular gland
- MeSH:
Animals;
Aquaporins*;
Autonomic Pathways;
Epithelial Sodium Channels;
Parasympathectomy;
Rats*;
Salivary Glands;
Sodium*;
Submandibular Gland*;
Sympathectomy
- From:The Korean Journal of Physiology and Pharmacology
2006;10(2):65-69
- CountryRepublic of Korea
- Language:English
-
Abstract:
The present study was undertaken to explore the role of autonomic nerves in the regulation of sodium transporters and water channels in the salivary gland. Rats were denervated of their sympathetic or parasympathetic nerves to the submandibular gland. One week later, the expression of Na,K-ATPase, epithelial sodium channels (ENaC), and aquaporins (AQP) was examined in the denervated and contralateral glands. The sympathetic denervation slightly but significantly decreased the expression of alpha1 subunit of Na,K-ATPase, whereas the parasympathetic denervation increased it. The expression of alpha-subunit of ENaC was significantly increased in both the denervated and contralateral glands either by the sympathetic or parasympathetic denervation. The sympathetic denervation significantly increased the expression of AQP5 in both the denervated and contralateral glands, whereas the parasympathetic denervation decreased it. It is suggested that the autonomic nerves have a tonic effect on the regulation of sodium transporters and AQP water channels in the salivary gland.
