Effects of Serotonin on the Induction of Long-term Depression in the Rat Visual Cortex.
10.4196/kjpp.2010.14.5.337
- Author:
Hyun Jong JANG
1
;
Kwang Hyun CHO
;
Sung Won PARK
;
Myung Jun KIM
;
Shin Hee YOON
;
Duck Joo RHIE
Author Information
1. Department of Physiology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea. djrhie@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
5-HT;
Development;
GABA;
Inhibition;
LTD;
Synaptic plasticity;
Visual cortex
- MeSH:
Animals;
Depression;
Dominance, Ocular;
gamma-Aminobutyric Acid;
Long-Term Potentiation;
Plastics;
Rats;
Serotonin;
Visual Cortex
- From:The Korean Journal of Physiology and Pharmacology
2010;14(5):337-343
- CountryRepublic of Korea
- Language:English
-
Abstract:
Long-term potentiation (LTP) and long-term depression (LTD) have both been studied as mechanisms of ocular dominance plasticity in the rat visual cortex. In a previous study, we suggested that a developmental increase in serotonin [5-hydroxytryptamine (5-HT)] might be involved in the decline of LTP, since 5-HT inhibited its induction. In the present study, to further understand the role of 5-HT in a developmental decrease in plasticity, we investigated the effect of 5-HT on the induction of LTD in the pathway from layer 4 to layer 2/3. LTD was inhibited by 5-HT (10 micrometer) in 5-week-old rats. The inhibitory effect was mediated by activation of 5-HT2 receptors. Since 5-HT also regulates the development of visual cortical circuits, we also investigated the role of 5-HT on the development of inhibition. The development of inhibition was retarded by chronic (2 weeks) depletion of endogenous 5-HT in 5-week-old rats, in which LTD was reinstated. These results suggest that 5-HT regulates the induction of LTD directly via activation of 5-HT2 receptors and indirectly by regulating cortical development. Thus, the present study provides significant insight into the roles of 5-HT on the development of visual cortical circuits and on the age-dependent decline of long-term synaptic plasticity.
