Effects of norepinephrine and neuropeptide Y on the contractility of small mesenteric artery from 2K1C and DOCA-salt hypertensive rats.
- Author:
Sang Chae NAM
1
;
Seongsu KANG
;
Wonjae KIM
;
Jongun LEE
Author Information
1. Department of Physiology, Chonnam University Medical School, 5 Hak-Dong, Dong-Gu, Kwangju, South Korea.
- Publication Type:Original Article
- MeSH:
Animals;
Baths;
Blood Pressure;
Desoxycorticosterone;
Hypertension;
Mesenteric Arteries*;
Neuropeptide Y*;
Neuropeptides*;
Norepinephrine*;
Rats*;
Rats, Sprague-Dawley;
Sympathetic Nervous System;
Transducers
- From:The Korean Journal of Physiology and Pharmacology
2000;4(1):55-61
- CountryRepublic of Korea
- Language:English
-
Abstract:
The present study was conducted to investigate the possible role of the sympathetic nervous system in two-kidney, one clip (2K1C) and deoxycorticosterone acetate (DOCA)-salt hypertension. 2K1C and DOCA-salt hypertension were made in Sprague-Dawley rats. Four weeks after induction of hypertension, systolic blood pressure measured in conscious state was significantly higher in 2K1C (216+/-18 mmHg) and DOCA-salt (205+/-29 mmHg) groups than that in control (128+/-4 mmHg). The third branches (<300 micrometer in outer diameter) of the mesenteric artery were isolated and cut into ring segments of 2apprx3 mm in length. Each ring segment was mounted in tissue bath and connected to a force displacement transducer for measurement of isometric tension. The arterial rings were contracted by application of norepinephrine (NE) in a dose-dependent manner. The amplitude of the NE-induced contraction of the vessels was significantly larger in hypertension than in control. The NE-induced contraction was significantly enhanced by neuropeptide Y (NPY) in hypertension. Reciprocally, NPY-elicited vasocontraction was increased by NE in hypertension. These results suggest that the sympathetic nervous system contributes to the development of 2K1C and DOCA-salt hypertension.
