Wide Spectrum of Inhibitory Effects of Sertraline on Cardiac Ion Channels.
10.4196/kjpp.2012.16.5.327
- Author:
Hyang Ae LEE
1
;
Ki Suk KIM
;
Sung Ae HYUN
;
Sung Gurl PARK
;
Sung Joon KIM
Author Information
1. Next-Generation Pharmaceutical Research Center, Korea Institute of Toxicology, Korea Research Institute of Chemical Technology, Daejeon 305-600, Korea.
- Publication Type:Original Article
- Keywords:
Antidepressant;
Cardiac;
Ion channel;
Selective serotonin reuptake inhibitor;
Sertraline
- MeSH:
Action Potentials;
Animals;
Arrhythmias, Cardiac;
HEK293 Cells;
Inhibitory Concentration 50;
Ion Channels;
Muscle Cells;
Rats;
Serotonin Uptake Inhibitors;
Sertraline
- From:The Korean Journal of Physiology and Pharmacology
2012;16(5):327-332
- CountryRepublic of Korea
- Language:English
-
Abstract:
Sertraline is a commonly used antidepressant of the selective serotonin reuptake inhibitors (SSRIs) class. In these experiments, we have used the whole cell patch clamp technique to examine the effects of sertraline on the major cardiac ion channels expressed in HEK293 cells and the native voltage-gated Ca2+ channels in rat ventricular myocytes. According to the results, sertraline is a potent blocker of cardiac K+ channels, such as hERG, IKs and IK1. The rank order of inhibitory potency was hERG >IK1> IKs with IC50 values of 0.7, 10.5, and 15.2 microM, respectively. In addition to K+ channels, sertraline also inhibited INa and ICa, and the IC50 values are 6.1 and 2.6 microM, respectively. Modification of these ion channels by sertraline could induce changes of the cardiac action potential duration and QT interval, and might result in cardiac arrhythmia.
