Neuroprotective Effect of 8-OH-DPAT on Long-term Sequelae from Prenatal Ischemia in Rats.
- Author:
Seoul LEE
1
;
Tie Yuan ZHANG
;
Gun Tae KIM
;
Hee Soo KIM
;
Jong Doo LEE
;
Jeong Won JAHNG
;
Dong Goo KIM
Author Information
1. Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea. dgkimpharm@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
5-HT1A receptor;
Neuroprotection;
Prenatal ischemia;
8-OH-DPAT;
Motor coordination;
Rat
- MeSH:
8-Hydroxy-2-(di-n-propylamino)tetralin*;
Animals;
Brain;
Cerebellum;
Cerebral Cortex;
Ischemia*;
Neuroprotective Agents*;
Pregnancy;
Rats*;
Receptor, Serotonin, 5-HT1A;
Serotonin;
Serotonin 5-HT1 Receptor Agonists
- From:The Korean Journal of Physiology and Pharmacology
2002;6(6):293-297
- CountryRepublic of Korea
- Language:English
-
Abstract:
The role of 5-hydroxytryptamine (5-HT)1A receptor activity in prenatal ischemia was studied, by injecting 8-hydroxy-dipropylaminotetraline (8-OH-DPAT; 50 microgram/kg, s.c.), a 5-HT1A agonist on gestation day 17, and 30 min later inducing transient ischemia by ligating the uterine vessels for 30 min. On postnatal day 95, rats that had experienced prenatal ischemia showed impaired motor coordination and reduced concentration of 5-HT in the cerebellum compared with Sham-operated controls. In addition, they showed increased 5-HT1A receptor densities in the cerebral cortex. Pretreatment with 8-OH-DPAT ameliorated the behavioral and neurochemical sequelae measured in the present study. The results suggest that 5-HT1A receptors protect the brain from ischemic insult and/or facilitate recovery after prenatally experienced ischemia.
