Selective cytotoxicity of a novel platinum (II) coordination complex on human gastric cancer cell lines and normal kidney cells.
- Author:
Jee Chang JUNG
1
;
Young Kyu KIM
;
Sung Vin YIM
;
Seung Joon PARK
;
Joo Ho CHUNG
;
Sung Goo CHANG
;
Kyung Tae LEE
;
Young Soo RHO
Author Information
1. Department of Pharmacology, School of Medicine, Kyung Hee University, Hoeki-dong, Dongdaemoon-ku, Seoul, 130-701 South Korea.
- Publication Type:Original Article
- Keywords:
Selective cytotoxicity;
Nephrotoxicity;
Platinum coordination complex
- MeSH:
Adenocarcinoma;
Cell Line*;
Cisplatin;
Glucose;
Humans*;
Kidney*;
Platinum*;
Stomach Neoplasms*
- From:The Korean Journal of Physiology and Pharmacology
1999;3(3):283-291
- CountryRepublic of Korea
- Language:English
-
Abstract:
We have synthesized novel platinum (II) coordination complex containing cis-1,2-diaminocyclohexane (DACH) as a carrier ligand and 1,2-bis(diphenylphosphino)ethane (DPPE) as leaving group. Furthermore, nitrate was added to improve the water-solubility. A new series of (Pt(cis-DACH)(DPPE)) cntdot 2NO3 (PC) was evaluated its antitumor activity on various MKN-45 human gastric adenocarcinoma cell-lines and normal primary cultured kidney cells. The new platinum complex demonstrated high efficacy in the cytotoxicity on MKN-45 cell-lines as well as adriamycin-resistant (MKN-45/ADR) and cisplatin-resistant (MKN-45/CDDP) cells. The cytotoxicities of PC were found quite less than those of cisplatin in rabbit proximal renal tubular cells, human renal cortical cells and human renal cortical tissues using MTT assay, (3H)-thymidine uptake and glucose consumption tests. Based on these results, this novel platinum (II) coordination complex, was considered as better a valuable lead for improving antitumor activities with low nephrotoxicities in the development of a new clinically available anticancer chemotherapeutic agents.
