Mechanical Hyperalgesia Induced by Blocking Calcium-activated Potassium Channels on Capsaicin-sensitive Afferent Fiber.
- Author:
Kyung Hee LEE
1
;
Hong Kee SHIN
Author Information
1. Department of Physiology, College of Medicine, Hanyang University, Seoul 133-791, Korea. shinhg@hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
Ca2+-activated K+ channel;
Mechanical sensitivity;
Capsaicin-sensitive primary afferent fiber
- MeSH:
Apamin;
Capsaicin;
Charybdotoxin;
Hyperalgesia*;
Neurons;
Potassium Channels, Calcium-Activated*
- From:The Korean Journal of Physiology and Pharmacology
2007;11(5):215-219
- CountryRepublic of Korea
- Language:English
-
Abstract:
Small and large conductance Ca2+-activated K+ (SKCa and BKCa) channels are implicated in the modulation of neuronal excitability. We investigated how changes in peripheral KCa channel activity affect mechanical sensitivity as well as the afferent fiber type responsible for KCa channel-induced mechanical sensitivity. Blockade of SKCa and BKCa channels induced a sustained decrease of mechanical threshold which was significantly attenuated by topical application of capsaicin onto afferent fiber and intraplantar injection of 1-ethyl-2-benzimidazolinone. NS1619 selectively attenuated the decrease of mechanical threshold induced by charybdotoxin, but not by apamin. Spontaneous flinching and paw thickness were not significantly different after KCa channel blockade. These results suggest that mechanical sensitivity can be modulated by KCa channels on capsaicin-sensitive afferent fibers.
