Impact of Micellar Vehicles on in situ Intestinal Absorption Properties of Beta-Lapachone in Rats.
- Author:
Soung Baek JANG
1
;
Dongju KIM
;
Seong Yeon KIM
;
Changhee PARK
;
Ji Hoon JEONG
;
Hyo Jeong KUH
;
Jaehwi LEE
Author Information
- Publication Type:Original Article
- Keywords: Beta-lapachone; Mixed micelles; Permeability; Single-pass intestinal perfusion
- MeSH: Absorption; Animals; Deoxycholic Acid; Intestinal Absorption; Intestine, Large; Mice; Micelles; Naphthoquinones; Perfusion; Permeability; Phosphatidylcholines; Rats; Sodium Dodecyl Sulfate
- From:The Korean Journal of Physiology and Pharmacology 2013;17(1):9-13
- CountryRepublic of Korea
- Language:English
- Abstract: The aim of the present study was to examine the effect of micellar systems on the absorption of beta-lapachone (b-lap) through different intestinal segments using a single-pass rat intestinal perfusion technique. B-lap was solubilized in mixed micelles composed of phosphatidylcholine and sodium deoxycholate, and in sodium lauryl sulfate (SLS)-based conventional micelles. Both mixed micelles and SLS micelles improved the in situ permeability of b-lap in all intestinal segments tested although the mixed micellar formulation was more effective in increasing the intestinal absorption of b-lap. The permeability of b-lap was greatest in the large intestinal segments. Compared with SLS micelles, the effective permeability coefficient values measured with mixed micelles were 5- to 23-fold higher depending on the intestinal segment. Our data suggest that b-lap should be delivered to the large intestine using a mixed micellar system for improved absorption.
