Taxifolin Glycoside Blocks Human ether-a-go-go Related Gene K+ Channels.
10.4196/kjpp.2013.17.1.37
- Author:
Jihyun YUN
1
;
Hyemi BAE
;
Sun Eun CHOI
;
Jung Ha KIM
;
Young Wook CHOI
;
Inja LIM
;
Chung Soo LEE
;
Min Won LEE
;
Jae Hong KO
;
Seong Jun SEO
;
Hyoweon BANG
Author Information
1. Department of Physiology, College of Medicine, Chung-Ang University, Seoul 156-756, Korea. haena@cau.ac.kr
- Publication Type:Original Article
- Keywords:
hERG K+ channel;
Long QT syndrome;
Patch clamp;
Taxifolin glycoside
- MeSH:
Dermatitis, Atopic;
Humans;
Long QT Syndrome;
Quercetin
- From:The Korean Journal of Physiology and Pharmacology
2013;17(1):37-42
- CountryRepublic of Korea
- Language:English
-
Abstract:
Taxifolin glycoside is a new drug candidate for the treatment of atopic dermatitis (AD). Many drugs cause side effects such as long QT syndrome by blocking the human ether-a-go-go related gene (hERG) K+ channels. To determine whether taxifolin glycoside would block hERG K+ channels, we recorded hERG K+ currents using a whole-cell patch clamp technique. We found that taxifolin glycoside directly blocked hERG K+ current in a concentration-dependent manner (EC50=9.6+/-0.7 microM). The activation curve of hERG K+ channels was negatively shifted by taxifolin glycoside. In addition, taxifolin glycoside accelerated the activation time constant and reduced the onset of the inactivation time constant. These results suggest that taxifolin glycoside blocks hERG K+ channels that function by facilitating activation and inactivation process.
